国家优秀青年基金获得者

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  • 赵凌
  • 系所

    预防兽医学系
  • 职称

    三级教授
  • 办公房间

    生猪健康养殖协同创新中心413
  • email

    lingzhao@mail.hzau.edu.cn
  • 讲授课程

    《细胞生物学C》、《人兽共患病进展》、《预防兽医学进展》、

个人简介

赵凌,男,湖北十堰人。必赢766net手机版教授、博士生导师。国家自然科学基金优秀青年科学基金(2015)、“3551光谷人才计划”获得者。必赢766net手机版农学学士、硕士,美国佐治亚大学兽医病毒学博士,美国宾夕法尼亚大学医学院微生物系博士后。兼任湖北实验动物学会副理事长,湖北省微生物学会理事。主要从事神经病毒学研究,包括病毒与宿主的相互作用研究,病毒的检测与鉴定,新型疫苗和佐剂的研发等。近年在Cell Host & Microbe 和Journal of Virology等期刊上发表第一作者或通讯作者文章10余篇。担任畜牧兽医学报,中国病毒学(海外版)和Journal of Neurovirology 等多个中外期刊的审稿人。曾于2010年获得美国兽医学会“优秀青年研究学者奖”,​2014年入选“3551光谷人才计划”,2015年获国家自然科学基金“优秀青年科学基金”资助。

教育经历

1996.09 - 2000.06, 必赢766net手机版,兽医专业,农学学士
2000.09 - 2003.06, 必赢766net手机版,预防兽医学,农学硕士
2004.09 - 2009.08, 美国佐治亚大学,兽医病毒学,博士

工作经历

2012.08-至今,必赢766net手机版动科-动医学院教授、博士生导师

研究领域

狂犬病毒致病与免疫机制、新型疫苗、佐剂与诊断制剂。

科研成果

A著作类
1.《Handbook of nucleic acid purification 》参编
B论文类
Zhao Wang, Qian Liang, Yajing Zhang, Jie Yang, Mingming Li, Kunlun Wang, Min Cui, Huanchun Chen, Zhen F. Fu, Ling Zhao*, Ming Zhou*. 2017. An optimized HMGB1 expressed by recombinant rabies virus enhances immunogenicity through activation of dendritic cells in mice. Oncotarget doi:10.18632/oncotarget.18368. (IF=5.0)
2.Chen T, Zhang Y, Wang Z, Yang J, Li M, Wang K, Cui M, Fu ZF, Zhao L*, Zhou M*. 2017. Recombinant rabies virus expressing IL-15 enhances immunogenicity through promoting the activation of dendritic cells in mice. Virol Sin 32:317-327.
3.Wang Z, Li M, Zhou M, Zhang Y, Yang J, Cao Y, Wang K, Cui M, Chen H, Fu ZF, Zhao L*. 2017. A Novel Rabies Vaccine Expressing CXCL13 Enhances Humoral Immunity by Recruiting both T Follicular Helper and Germinal Center B Cells. J Virol 91. (IF=4.6)
4.Li Y, Zhou M, Luo Z, Zhang Y, Cui M, Chen H, Fu ZF, Zhao L*. 2017. Overexpression of IL-7 extends the humoral immune response induced by rabies vaccination. J Virol doi:10.1128/JVI.02324-16. (IF=4.6)
5.Zhang Y, Zhou M, Wang Z, Yang J, Li M, Wang K, Cui M, Chen H, Fu ZF, Zhao L*. 2016. Recombinant rabies virus expressing IL-21 enhances immunogenicity through activation of T follicular helper cells and germinal centre B cells. J Gen Virol 97:3154-3160. (IF=3.2)
6.Tian D, Luo Z, Zhou M, Li M, Yu L, Wang C, Yuan J, Li F, Tian B, Sui B, Chen H, Fu ZF, Zhao L*. 2016. Critical Role of K1685 and K1829 in the Large Protein of Rabies Virus in Viral Pathogenicity and Immune Evasion. J Virol 90:232-244. (IF=4.4)
7.Sui B, Huang J, Jha BK, Yin P, Zhou M, Fu ZF, Silverman RH, Weiss SR, Peng G, Zhao L*. 2016. Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation. J Gen Virol doi:10.1099/jgv.0.000395. (IF=3.2)
8.Navid MT, Li Y, Zhou M, Cui M, Fu ZF, Tang L, Zhao L*. 2016. Comparison of the immunogenicity of two inactivated recombinant rabies viruses overexpressing the glycoprotein. Arch Virol 161:2863-2870. (IF=2.3)
9.Zhou M WL, Zhou S, Wang Z, Ruan J, Tang L, Jia Z, Cui M, Zhao L*, Fu ZF*. 2015. Recombinant rabies virus expressing dog GM-CSF is an efficacious oral rabies vaccine for dogs. Oncotarget (IF=5.0)
10.Luo Z, Tian D, Zhou M, Xiao W, Zhang Y, Li M, Sui B, Wang W, Guan H, Chen H, Fu ZF, Zhao L*. 2015. lambda-Carrageenan P32 Is a Potent Inhibitor of Rabies Virus Infection. PLoS One 10:e0140586. (IF=3.0)
11.Zhao L, Birdwell LD, Wu A, Elliott R, Rose KM, Phillips JM, Li Y, Grinspan J, Silverman RH, Weiss SR. 2013. Cell-Type-Specific Activation of the Oligoadenylate Synthetase-RNase L Pathway by a Murine Coronavirus. J Virol 87:8408-8418. (IF=5.0)
12.Zhao L, Jha BK, Wu A, Elliott R, Ziebuhr J, Gorbalenya AE, Silverman RH, Weiss SR. 2012. Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Cell Host Microbe 11:607-616. (IF=12.6)
13.Zhao L, Rose KM, Elliott R, Van Rooijen N, Weiss SR. 2011. Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus. J Virol 85:10058-10068. (IF=5.1)
14.Zhao L, Toriumi H, Wang H, Kuang Y, Guo X, Morimoto K, Fu ZF. 2010. Expression of MIP-1alpha (CCL3) by a recombinant rabies virus enhances its immunogenicity by inducing innate immunity and recruiting dendritic cells and B cells. J Virol 84:9642-9648. (IF=5.1)
15.Zhao L, Toriumi H, Kuang Y, Chen H, Fu ZF. 2009. The roles of chemokines in rabies virus infection: overexpression may not always be beneficial. J Virol 83:11808-11818. (IF=5.1)

科研项目

1. 狂犬病病毒mRNA加帽酶对病毒致病性和免疫逃避的影响, 国家自然科学基金(面上项目), 2014-2017
2. 兽医传染病学, 国家自然科学基金(优青), 2016-2018
3. 重要神经嗜性人兽共患病免疫与致病机制研究-病原诱导天然免疫应答及其调控机制研究, 国家重点研发计划子课题,2016-2020

主要奖励

2014年入选“3551光谷人才计划”
2015年获国家自然科学基金“优秀青年科学基金”资助
2016年获“武汉市优秀青年科技工作者

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