师资队伍
国家优秀青年基金获得者
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赵凌,男,湖北十堰人。必赢766net手机版教授、博士生导师。国家自然科学基金优秀青年科学基金(2015)、“3551光谷人才计划”获得者。必赢766net手机版农学学士、硕士,美国佐治亚大学兽医病毒学博士,美国宾夕法尼亚大学医学院微生物系博士后。兼任湖北实验动物学会副理事长,湖北省微生物学会理事。主要从事神经病毒学研究,包括病毒与宿主的相互作用研究,病毒的检测与鉴定,新型疫苗和佐剂的研发等。近年在Cell Host & Microbe 和Journal of Virology等期刊上发表第一作者或通讯作者文章10余篇。担任畜牧兽医学报,中国病毒学(海外版)和Journal of Neurovirology 等多个中外期刊的审稿人。曾于2010年获得美国兽医学会“优秀青年研究学者奖”,2014年入选“3551光谷人才计划”,2015年获国家自然科学基金“优秀青年科学基金”资助。
1996.09 - 2000.06, 必赢766net手机版,兽医专业,农学学士2000.09 - 2003.06, 必赢766net手机版,预防兽医学,农学硕士2004.09 - 2009.08, 美国佐治亚大学,兽医病毒学,博士
2012.08-至今,必赢766net手机版动科-动医学院教授、博士生导师
狂犬病毒致病与免疫机制、新型疫苗、佐剂与诊断制剂。
A著作类1.《Handbook of nucleic acid purification 》参编B论文类Zhao Wang, Qian Liang, Yajing Zhang, Jie Yang, Mingming Li, Kunlun Wang, Min Cui, Huanchun Chen, Zhen F. Fu, Ling Zhao*, Ming Zhou*. 2017. An optimized HMGB1 expressed by recombinant rabies virus enhances immunogenicity through activation of dendritic cells in mice. Oncotarget doi:10.18632/oncotarget.18368. (IF=5.0)2.Chen T, Zhang Y, Wang Z, Yang J, Li M, Wang K, Cui M, Fu ZF, Zhao L*, Zhou M*. 2017. Recombinant rabies virus expressing IL-15 enhances immunogenicity through promoting the activation of dendritic cells in mice. Virol Sin 32:317-327.3.Wang Z, Li M, Zhou M, Zhang Y, Yang J, Cao Y, Wang K, Cui M, Chen H, Fu ZF, Zhao L*. 2017. A Novel Rabies Vaccine Expressing CXCL13 Enhances Humoral Immunity by Recruiting both T Follicular Helper and Germinal Center B Cells. J Virol 91. (IF=4.6)4.Li Y, Zhou M, Luo Z, Zhang Y, Cui M, Chen H, Fu ZF, Zhao L*. 2017. Overexpression of IL-7 extends the humoral immune response induced by rabies vaccination. J Virol doi:10.1128/JVI.02324-16. (IF=4.6)5.Zhang Y, Zhou M, Wang Z, Yang J, Li M, Wang K, Cui M, Chen H, Fu ZF, Zhao L*. 2016. Recombinant rabies virus expressing IL-21 enhances immunogenicity through activation of T follicular helper cells and germinal centre B cells. J Gen Virol 97:3154-3160. (IF=3.2)6.Tian D, Luo Z, Zhou M, Li M, Yu L, Wang C, Yuan J, Li F, Tian B, Sui B, Chen H, Fu ZF, Zhao L*. 2016. Critical Role of K1685 and K1829 in the Large Protein of Rabies Virus in Viral Pathogenicity and Immune Evasion. J Virol 90:232-244. (IF=4.4)7.Sui B, Huang J, Jha BK, Yin P, Zhou M, Fu ZF, Silverman RH, Weiss SR, Peng G, Zhao L*. 2016. Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation. J Gen Virol doi:10.1099/jgv.0.000395. (IF=3.2)8.Navid MT, Li Y, Zhou M, Cui M, Fu ZF, Tang L, Zhao L*. 2016. Comparison of the immunogenicity of two inactivated recombinant rabies viruses overexpressing the glycoprotein. Arch Virol 161:2863-2870. (IF=2.3)9.Zhou M WL, Zhou S, Wang Z, Ruan J, Tang L, Jia Z, Cui M, Zhao L*, Fu ZF*. 2015. Recombinant rabies virus expressing dog GM-CSF is an efficacious oral rabies vaccine for dogs. Oncotarget (IF=5.0)10.Luo Z, Tian D, Zhou M, Xiao W, Zhang Y, Li M, Sui B, Wang W, Guan H, Chen H, Fu ZF, Zhao L*. 2015. lambda-Carrageenan P32 Is a Potent Inhibitor of Rabies Virus Infection. PLoS One 10:e0140586. (IF=3.0)11.Zhao L, Birdwell LD, Wu A, Elliott R, Rose KM, Phillips JM, Li Y, Grinspan J, Silverman RH, Weiss SR. 2013. Cell-Type-Specific Activation of the Oligoadenylate Synthetase-RNase L Pathway by a Murine Coronavirus. J Virol 87:8408-8418. (IF=5.0)12.Zhao L, Jha BK, Wu A, Elliott R, Ziebuhr J, Gorbalenya AE, Silverman RH, Weiss SR. 2012. Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Cell Host Microbe 11:607-616. (IF=12.6)13.Zhao L, Rose KM, Elliott R, Van Rooijen N, Weiss SR. 2011. Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus. J Virol 85:10058-10068. (IF=5.1)14.Zhao L, Toriumi H, Wang H, Kuang Y, Guo X, Morimoto K, Fu ZF. 2010. Expression of MIP-1alpha (CCL3) by a recombinant rabies virus enhances its immunogenicity by inducing innate immunity and recruiting dendritic cells and B cells. J Virol 84:9642-9648. (IF=5.1)15.Zhao L, Toriumi H, Kuang Y, Chen H, Fu ZF. 2009. The roles of chemokines in rabies virus infection: overexpression may not always be beneficial. J Virol 83:11808-11818. (IF=5.1)
1. 狂犬病病毒mRNA加帽酶对病毒致病性和免疫逃避的影响, 国家自然科学基金(面上项目), 2014-20172. 兽医传染病学, 国家自然科学基金(优青), 2016-20183. 重要神经嗜性人兽共患病免疫与致病机制研究-病原诱导天然免疫应答及其调控机制研究, 国家重点研发计划子课题,2016-2020
2014年入选“3551光谷人才计划”2015年获国家自然科学基金“优秀青年科学基金”资助2016年获“武汉市优秀青年科技工作者
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