个人简介

申邦，男，1982年9月生，湖南衡阳人。必赢766net手机版教授、博士生导师，国家杰出青年基金获得者（2023）、优秀青年科学基金获得者（2018）。2005年本科毕业于武汉大学生科院， 2010年获美国堪萨斯大学微生物学博士学位，2010年至2014年间在华盛顿大学从事博士后研究。2014年12月入职必赢766net手机版必赢766net手机版，主要研究人兽共患病原的感染致病机制和防控策略，从营养代谢及其调控的角度探索弓形虫营寄生生活的分子机理。2015年来先后主持国家自然科学基金、国家重点研发计划、霍英东青年教师基金等研究课题6项。以第一或通讯作者在PNAS、mBio、Cellular Microbiology等国际学术期刊发表论文20余篇, 参编英文专著1部，申报专利4项并获得保护力近100%的弓形虫新型疫苗。担任中国动物学会寄生虫学专业委员会青年委员以及Frontiers in Microbiology客座编委和浙江大学学报(农业与生命科学版)编委。

教育经历

2001.09 - 2005.07，武汉大学，生物科学专业毕业，学士
2005.08 - 2010.08，堪萨斯大学，微生物学专业毕业，博士

工作经历

2010.12-2014.11，华盛顿大学医学院，博士后。
2014.12-现在，必赢766net手机版教授、博士生导师。

研究领域

真核病原的致病机制、人兽共患病、基因编辑、动物疫苗

科研成果

A著作类
B论文类
Xia N, Yang J, Ye S, Zhang L, Zhou Y, Zhao J, David Sibley L, Shen B*. Functional analysis of Toxoplasma lactate dehydrogenases suggests critical roles of lactate fermentation for parasite growth in vivo. Cell Microbiol. 2017 Oct 13. doi: 10.1111/cmi.12794.

Pan M, Lyu C, Zhao J, Shen B*. Sixty Years (1957-2017) of Research on Toxoplasmosis in China-An Overview. Front Microbiol. 2017 Sep 25;8:1825. doi: 10.3389/fmicb.

Shen B*, Powell RH, Behnke MS*. QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii. J Vis Exp. 2017 Jun 22;(124). doi: 10.3791/55185.
Shen B, Yuan Y, Cheng J, Pan M, Xia N, Zhang W, Wang Y, Zhou Y, Zhao J. Activation of chronic toxoplasmosis by transportation stress in a mouse model. Oncotarget, 2016 Dec 27;7(52):87351-87360

Shen B, Brown K, Long S, Sibley LD. Development of CRISPR/Cas9 for Efficient Genome Editing in Toxoplasma gondii. Methods Mol Biol. 2017;1498:79-103.
Wang JL, Huang SY, Behnke MS, Chen K, Shen B*, Zhu XQ*, The Past, Present, and Future of Genetic Manipulation in Toxoplasma gondii. Trends Parasitol. 2016 Jul;32(7):542-53
Zhang W, Li L, Xia N, Zhou Y, Fang R, He L, Hu M, Shen B*, Zhao J*. Analysis of the virulence determination mechanisms in a local Toxoplasma strain (T.gHB1) isolated from central China. Parasitol Res. 2016 Oct;115(10):3807-15
Wang Y, Fang R, Yuan Y, Pan M, Hu M, Zhou Y, Shen B, Zhao J*. Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3. Parasitol Res. 2016, 115(7):2825-35
Huang Y, He L*, Hu J, Miao XY, He P, He JW, Yu L, Ngabu Malobi, Zhou YQ, Shen B, Zhao JL*. Characterization and annotation of Babesia orientalis apicoplast genome. Parasites & Vectors. 2015 Oct 16;8(1):543.
He L, Fan LZ, Liu Q, Hu J, Miao XY, Huang Y, He P, He JW, Yu L, Muhammad K, Zhou YQ, Shen B, Zhao JL*. Identification and characterization of a novel 34 kDa merozoite protein in Babesia orientalis. Vet. Parasitol. 2015 Sep. 15;212(3-4):411-6.
Bang Shen & L David Sibley. (2014) Toxoplasma aldolase is required for metabolism but dispensable for host cell invasion. PNAS. 111(9):3567-72.
Bang Shen, Kevin Brown, Tobie D Lee & L David Sibley. (2014) Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9. mBio, 13;5(3):e01114-14
Bang Shen, Jeffrey S. Buguliskis, Tobie D. Lee & L. David Sibley. (2014) Functional analysis of rhomboid proteases during Toxoplasma invasion. mBio;5(5):e01795-14
Bang Shen & L David Sibley. (2012) The moving junction, a key portal to host cell invasion by apicomplexan parasites. Current Opinion in Microbiology. 15(4):449-55
Bang Shen & Joe Lutkenhaus. (2009) The conserved C-terminal tail of FtsZ is required for the septal localization and division inhibitory activity of MinCC/MinD. Molecular Microbiology. 72(2) 410-424.
Bang Shen & Joe Lutkenhaus. (2010) Examination of the interaction between FtsZ and MinCN in E. coli suggests how MinC disrupts Z rings. Molecular Microbiology. 75: 1285-1298.
Bang Shen & Joe Lutkenhaus. (2011) Differences in MinC/MinD sensitivity between polar and internal Z rings in Escherichia coli. Journal of Bacteriology. 193(2):367-76.
Sebastien Pichoff, Bang Shen, Bradley Sullivan, Joe Lutkenhaus. (2012) FtsA mutants impaired for self-interaction bypass ZipA suggesting a model in which FtsA

科研项目

1.必赢766net手机版引进人才启动资金， 2015 - 2019
2.乳酸脱氢酶LDH2在弓形虫缓殖子分化发育中的作用及调节机制 2016.01- 2019.12
3. 弓形虫病现场诊断技术与基因缺失疫苗研究 2017.01-2020.12
4. 胞内寄生原虫在宿主细胞内的生长发育特征及调控机理2017.01-2020.12

主要奖励

1. 美国华盛顿大学Alexander & Gertrude Berg 博士后研究基金, 2011
2.美国堪萨斯大学Remi Amelunxen 杰出研究成就奖, 2010
4. 湖北省学士学位论文一等奖,2005